International Journal of Medicine and Health Development

ARTICLE
Year
: 2012  |  Volume : 17  |  Issue : 2  |  Page : 24--29

Analysis of the responses of rats ileum to the effect of aqueous rhizome extract of zingiber officinale


F Agoreyo, M Omigie, P Itebiye 
 Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria

Correspondence Address:
F Agoreyo
Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City
Nigeria

Background: The gastrointestinal system is innervated by the sympathetic and parasympathetic components of the autonomic nervous system (ANS). ANS mediate its effect by the release of acetylcholine, a neurotransmitter secreted by the parasympathetic nervous system. Its stimulation produces increase intestinal motility, sphincter muscle relaxation and stimulation of secretion. The actions of acetylcholine can be blocked by using a cholinergic receptor, antagonist such as atropine. Aims: This study is aimed at determining the effect of aqueous rhizome extract of Zingiber officinale on an isolated rat ileum Result: The aqueous extract of Zingiber officinale produced similar effect as atropine, as seen when varied increasing doses(1mg/ml, 2mg/ml, 4mg/ml) of the extract was administered. It produced significant inhibition (P< 0.05) at 1mg/ml (P< 0.01) at 2mg/ml (P< 0.001) and at 4mg/ml intestinal motility respectively , indicating anti diarrhoea effect.


How to cite this article:
Agoreyo F, Omigie M, Itebiye P. Analysis of the responses of rats ileum to the effect of aqueous rhizome extract of zingiber officinale.Int J Med Health Dev 2012;17:24-29


How to cite this URL:
Agoreyo F, Omigie M, Itebiye P. Analysis of the responses of rats ileum to the effect of aqueous rhizome extract of zingiber officinale. Int J Med Health Dev [serial online] 2012 [cited 2023 Feb 8 ];17:24-29
Available from: https://www.ijmhdev.com/article.asp?issn=2635-3695;year=2012;volume=17;issue=2;spage=24;epage=29;aulast=Agoreyo;type=0