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ORIGINAL ARTICLE
Year : 2022  |  Volume : 27  |  Issue : 4  |  Page : 344-349

The effect of avocado seed extract (Persea Americana) on carbide induced hepatoxicity in adult Wistar rats


1 Department of Human Anatomy, Nnamdi Azikiwe University, Nnewi, Nigeria
2 Department of Obstetrics and Gynecology, Nnamdi Azikiwe University and Teaching Hospital, Nnewi, Nigeria; Centre for Health and Allied Legal and Demographical Development Research and Training (CHALADDRAT), Nnamdi Azikiwe University, Awka, Nigeria
3 Centre for Health and Allied Legal and Demographical Development Research and Training (CHALADDRAT), Nnamdi Azikiwe University, Awka, Nigeria; Department of Human Biochemistry, Nnamdi Azikiwe University, Nnewi, Nigeria

Correspondence Address:
Joseph I Adinma
Department of Obstetrics and Gynecology, Nnamdi Azikiwe University and Teaching Hospital, Nnewi
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijmh.ijmh_21_22

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Background: Persea Americana is reported to have medicinal value. Calcium Carbide (CaC2), a fruit-ripening agent, has been shown to be toxic to body organs. Objective: To determine the effect of avocado seed extract (ASE) on CaC2-induced hepatotoxicity in rats. Materials and Methods: Four experimental groups, each of 5 adult wistar rats were fed respectively with normal diets (group A); 250 mg/kg ASE (group B); 100 mg/kg CaC2 (group C); combination of 100 mg/kg CaC2 and 250 mg/kg ASE – group D. Changes in the rats’ behaviours, body weights, and liver function were assessed over 21 days. Data were analyzed using SPSS. The cumulated rat weights, rat liver weights and serum liver enzyme levels for groups B, C, and D rats were compared with group A. Results: Abnormal behavior was most observed in group C rats. Rats in group A showed a significant increase in weight before and three weeks following administration of feeds while rats in groups B, C, and D showed significant decrease in weight – more marked in group C rats. Only the mean liver weights of rats in group C showed significant decrease compared to that in group A, P = 0.001. Similarly, only the cumulated liver enzyme levels of rats in group C demonstrated significant increase when compared to group A rats - indicating hepatotoxicity. Conclusion: In this study, hepatotoxicity occurred in CaC2-administered rats. However, the combination of CaC2 and ASE showed no liver toxicity indicating a mitigating effect of ASE to CaC2-induced hepatotoxicity.


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