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ARTICLE
Year : 2012  |  Volume : 17  |  Issue : 2  |  Page : 24-29

Analysis of the responses of rats ileum to the effect of aqueous rhizome extract of zingiber officinale


Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria

Correspondence Address:
F Agoreyo
Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4314/jcm.v17i2.3

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Background: The gastrointestinal system is innervated by the sympathetic and parasympathetic components of the autonomic nervous system (ANS). ANS mediate its effect by the release of acetylcholine, a neurotransmitter secreted by the parasympathetic nervous system. Its stimulation produces increase intestinal motility, sphincter muscle relaxation and stimulation of secretion. The actions of acetylcholine can be blocked by using a cholinergic receptor, antagonist such as atropine. Aims: This study is aimed at determining the effect of aqueous rhizome extract of Zingiber officinale on an isolated rat ileum Result: The aqueous extract of Zingiber officinale produced similar effect as atropine, as seen when varied increasing doses(1mg/ml, 2mg/ml, 4mg/ml) of the extract was administered. It produced significant inhibition (P< 0.05) at 1mg/ml (P< 0.01) at 2mg/ml (P< 0.001) and at 4mg/ml intestinal motility respectively , indicating anti diarrhoea effect.


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