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Year : 2009  |  Volume : 14  |  Issue : 2  |  Page : 85-88

Membranoproliferative glomerulonephritis in a Nigerian adolescent with congenital solitary kidney: Unraveling the cause of mortality

1 Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria
2 Department of Morbid Anatomy, University of Nigeria Teaching Hospital, Enugu, Nigeria

Correspondence Address:
S N Uwaezoke
Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu
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Source of Support: None, Conflict of Interest: None

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Background: Unilateral renal agenesis (URA) or solitary kidney usually presents as non-ectopic solitary functioning kidney (SFK) with absent contra-lateral kidney. Although it is compatible with normal longevity, recent studies indicate that arterial hypertension, proteinuria, impaired renal function as well as glomerulosclerosis are potential complications. Case Report: We report a male adolescent patient who presented pre-mortem with features of acute renal failure and lobar pneumonia. Post-mortem examination revealed a solitary kidney with light microscopic findings suggesting membranoproliferative glomerulonephritis (MPGN) as the fundamental disease. The short duration of hospitalization and paucity of diagnostic facilities precluded a more accurate confirmation and classification of the glomerular disease. This report however highlights possible pathological scenarios, as well as the handicaps in the practice of Nephrology in this environment.

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