• Users Online: 322
  • Print this page
  • Email this page
ARTICLE
Year : 2009  |  Volume : 14  |  Issue : 1  |  Page : 6-13

Nephroprotective activity of stem bark extracts of canarium schweinfurthii on Acetaminophen-Induced renal injuries in rats


1 Department of Medical Laboratory Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria
2 Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria
3 Department of Medical Biochemistry, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria

Correspondence Address:
C N Okwuosa
Department of Medical Laboratory Sciences, Faculty of Health Sciences & Technology, College of Medicine, University of Nigeria, Enugu Campus
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Background: Canarium Schweinfurthii is a tropical plant which has been found useful in the treatment of various ailments such as diabetes mellitus, fever, constipation, malaria,diarrhoea and sexually transmitted diseases. It also possess antioxidant activity and scientific research has shown that medicinal plants with such ability may possess nephroprotective effect. Acetaminophen(paracetamol) is known to be toxic to the kidney especially during starvation, alcohol ingestion and in patients that take drugs that stimulate the P450 microsomal oxidase enzymes. Aims and Objectives: This study is aimed at evaluating the protective effects of aqueous and methanol extracts of stem bark of canarium schweinfurthii on the kidney when acetaminophen is used to induce renal injury in rats. Materials and Methods: Twenty-eight male albino rats weighing 150-200g were used for this study. They were divided into seven groups( A-G) of four rats per group. Two cumulative doses of aqueous extract(AE) and methanol extract(ME) were administered to groups A-D prior to oral administration of acetaminophen(500mg/kg). Groups E-G served as acetaminophen, negative(vehicle) and baseline controls respectively. The negative control group was given 3% tween 80 while the baseline control group was given only distilled water. Drug administration lasted for thirty days. Results: Blood urea and serum creatinine levels were significantly higher(p<0.01) in acetaminophen and negative control groups compared to baseline control group and the AE and ME groups. Histopathological examination shows that the extracts preserved the renal histoarchitecture while the acetaminophen and negative control groups showed varying degrees of inflammatory cells infiltration, necrosis,tubular casts, tubular erosion and increased urinary pole. Conclusion: The fall in plasma levels of urea and creatinine in AE and ME treated groups in the presence of acetaminophen suggests an improvement of renal function which is further supported histologically by a well preserved histoarchitecture in these groups.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed485    
    Printed30    
    Emailed0    
    PDF Downloaded78    
    Comments [Add]    

Recommend this journal