• Users Online: 486
  • Print this page
  • Email this page
ARTICLE
Year : 2008  |  Volume : 13  |  Issue : 1  |  Page : 7-12

Ivermectin therapy for onchocerciasis: Effect on some haematological and biochemical parameters


1 Department of Pharmacology & Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria
2 Department of Medical Laboratory Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria

Correspondence Address:
E N Shu
Department of Pharmacology & Therapeutics, College of Medicine, University of Nigeria, Enugu Campus
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objective: To investigate leucocyte mobilization, acid phosphatase and acetylcholinesterase activities during ivermectin therapy for onchocerciasis, to shed light on the mechanism underlying the involvement of the host's immune system. Method: A single oral dose of ivermectin (300 g/kg) was administered to 78 subjects (42 patients and 36 non-infected) aged between 14 and 40 years. Blood samples were collected from the subjects prior to the administration of the drug at 3, 7 and 14 days post-treatment. Results: There was no significant increase (P>0.05) in all the blood cell types throughout the study period. Significant increases (P<0.05) were observed in mean neutrophil and eosinophil counts on day 3 and days 0, 3, 7, and 14, respectively in the patients than in the controls. Mean lymphocyte counts were also significantly decreased (p<0.05) on days 3, 7 and 14 in the patients than in the controls. Both acid phosphatase and acetylcholinesterase activities were not significantly altered (p>0.05) throughout the study period. Conclusion: Killing of microfilariae by radicals generated from neutrophils; and the enhancement of eosinophils against Onchocerca volvulus after treatment with ivermectin is hereby suggested.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed400    
    Printed30    
    Emailed0    
    PDF Downloaded75    
    Comments [Add]    

Recommend this journal