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Year : 2001  |  Volume : 6  |  Issue : 2  |  Page : 109-112

Current clinical efficacy of chloroquine for the treatment of plasmodium falciparum infections in Ugwogo-Nike, Enugu East Local Government Area Of Enugu State, Nigeria

Department of Community Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria

Correspondence Address:
Chidi O Akahara
Department of Community Medicine, U.N.T.H, Enugu
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Source of Support: None, Conflict of Interest: None

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Background: There has been persistent report of increasing rate of chloroquine resistance in Plasmodium faciparum malaria in Nigeria. The present study is aimed at assessing the current level of chloroquine resistance among under five children in Ugwogo-Nike, Enugu East Local Government Area Enugu State. Materials and Methods: One hundred and five under-five children with microscopically confirmed falciparum malaria were given the standard oral chloroquine therapy (l0mg/kg days 1 and 2; 5mg/kg day 3). Using the 14-day WHO protocol, they were followed up. Results: Treatment failure was recorded in 33% of the cases, 20% of which were early treatment failure, the remaining 13% being late treatment failure. Conclusion: We conclude that the clinical efficacy of chloroquine as a first line therapy in this environment is low.

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