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Year : 1997  |  Volume : 2  |  Issue : 1  |  Page : 9-11

Alpha-1-antichymotrypsin levels in apparently normal adult blood donors and in disease conditions

Department of Chemical Pathology University Nigeria Teaching Hospital, Enugu, Nigeria

Correspondence Address:
A C J. Ezeoke
Department of Chemical Pathology University of Nigeria, Enugu Campus, Enugu
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Source of Support: None, Conflict of Interest: None

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Serum alpha-l-antichymotrypsin (ACT) levels were determined by single radial immunodiffusion in two hundred (200) apparently healthy blood donors and in one hundred patients with the following diseases - nephrotic syndrome 38, multiple myeloma 30, hepatoma 17, prostatic carcinoma 17 and lymphoma 5. The mean and standard deviation obtained were control 156 ± 71.2 ug/ml, nephrotic syndrome 197.6 ± 112.1 ug/ml, multiple myeloma 220.2 ± 162.4 ug/ml, prostatic carcinoma 465.4 ± 138.1 ug/ml, hepatoma 466.1 ± 143.9 ug/ml and lymphoma 331.2 ± 88.5 ug/ml. When compared with the control these figures were found to be statistically significantly higher (p < 0.0001). It is possible that the measurement of this acute phase protein could be of prognostic value.

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