Oral sultamicillin as prophylaxis in prostatectomy
Aloy E Aghaji
Urology Unit, Department of Surgery University of Nigeria Teaching Hospital, Enugu, Nigeria
FRCS, FWACS Aloy E Aghaji Dept. of Surgery U.N.T.H., Enugu Nigeria
Source of Support: None, Conflict of Interest: None
Sultamicillin, a double ester in which ampicillin and beta-lactamase inhibitor sulbactam are linked via a methylene group, was compared in a randomised controlled trial, with ampicilin as prophylaxis for prostatectomy. A 7-day course of peri-operative sultmicillin 375mg twice daily was compared with a 7-day course of Peri-operative ampicillin four times daily. It was found that sultamicillin significantly reduced the post-operative bacteriuria and frequency of infective complications. Sultamicillin was well tolerated and no significant haematological or biochemical side effects were detected. It is administered by mouth and only taken twice daily. These qualities make it much preferred by patients. The use of sultamicillin in prostatectomy prophylaxis would appear to be justified.