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ARTICLE
Year : 1996  |  Volume : 1  |  Issue : 1  |  Page : 23-27

A prospective study of post-transfusion hepatitis in an area of high hepatitis B virus prevalence: Incidence and risk factors


1 Department of Medicine, College of Medicine University of Nigeria, Enugu, Nigeria
2 Department of Haematology and Immunology, College of Medicine University of Nigeria, Enugu, Nigeria

Correspondence Address:
M.B.B.S, F.M.C.P B Onyenekwe
Department of Medicine, College of Medicine University of Nigeria, Enugu
Nigeria
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Source of Support: None, Conflict of Interest: None


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Forty-three patients who received 104 units of blood (2.4 units per patient) were prospectively followed for 6 months. Post transfusion hepatitis developed in 5(11.6%) of the patients; in 3 of them it was icteric while it was anicteric in 2. The attack rate of post-transfusion hepatitis was 48/1000 units transfused. The major risk factors for the development of post-transfusion hepatitis were the number of units of blood transfused, and the use of HBsAg positive blood. Also, the risk increased with the number of units of HBsAg positive blood given. The concentration of the aminotransferases in the donor blood, and the age and sex of the recipients had no relationship with the development of post-transfusion hepatitis. Most of post-transfusion hepatitis in our patients was related to hepatitis B virus.


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